Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp193 | Genetics | ECTS2014

MK-7 enhances expression of genes related to bone, enamel and dentin, and reduces the expression of genes related to apoptosis in developing murine molars

Landin Maria A. , Shabestari Yashar , Sehic Amer , Osmundsen Harald

Introduction: The fat-soluble and vitamin K2 homologe Menaquinone-7 (MK-7) is needed for post-translational modification of proteins essential in blood coagulation, and in metabolic pathways in various tissues like bone. Recent studies found an association between long-term anticoagulant treatment (OAC) and reduced bone quality due to reduction of active osteocalcin. OAC is often linked to an undesired soft-tissue calcification in both children and adults and may lead to incre...